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Download a nice colourfull chart of anticancer foods and the dirty dozen highly sprayed foods which should be organic whenever possible.

A plant-based diet can reduce the risk of breast cancer, according to a new study published online in the American Journal of Clinical Nutrition.

Researchers followed 91,779 current and retired California teachers for 14 years. Those who had a predominantly plant-based diet had a 15 percent reduced risk of breast cancer compared with those who did not include abundant fruits and vegetables in their diets.

The data showed a 34 percent decrease in the risk for a particular type of breast cancer, called estrogen and progesterone receptor negative, for those following a predominantly plant-based diet.

The researchers also found that a diet they called the salad and wine diet increased by 29 percent the risk of a different type of breast cancer, called estrogen and progesterone receptor positive.

The study divded the teachers into five diet groups:

  1. Plant-based diet rich in fresh fruit and vegetables
  2. High-protein/high fat diet - as recommended by the GAPS , Paelo , and Atkins diets - high in meat and animal fats
  3. High-carbohydrate diet - you guessed it - pizza, pasta, beans
  4. Ethnic diet - in this study, it seems to have been a Mexican type diet rich in beans, rice, soy, soups
  5. Salad and wine diet - wine, champagne, fish, chicken, sea food, salad, coffee and tea (in other words, a few token vegetables in salads or salad sandwiches). Taking out the effect of wine drinking did not reduce the cancer risk, in other words, it does not seem to be the wine which was the cause of the increased risk but the lack of vegetables. Lettuce is simply not enough.

There is simply no doubt about it: a plant-based diet, that is a diet, very high in vegetables, with some fruits, is, and will always be the healthiest diet to reduce the risk of cancer and just about any other disease you can think off.

Here is a photo of our fridge on a good day - usually after the Sunday Farmer's market.

Note it is called a plant-based diet. If you eat your vegies, you can enjoy a little meat or fish and a glass of wine and it will still lower your risk of cancer and serious disease.

Ref: Link LB et al. Dietary patterns and breast cancer risk in the California Teachers Study cohort. Am J Clin Nutr 2013 98(6): 1524-32

New research just published finds that ginger powder may be beneficial for people suffering type 2 diabetes.
The randomized, double-blind, placebo controlled trial involved 88 subjects affected by diabetes. They were given 3 one-gram capsules of ginger powder for a period of 8 weeks.

The researchers found that the ginger reduced fasting blood glucose levels (decreased 10.5%) and HbA1c levels.

Ginger also improved insulin sensitivity - that is it may it easier for cells to take up the glucose from the blood and thereby reducing the overall blood sugar level.

The placebo group on the other hand experienced a 21% increase in fasting blood glucose.

3 g of ginger powder is probably equivalent to about 15 g of fresh ginger which is a fair bit of ginger to eat everyday but it is possible. You can grate fresh ginger for chai or ginger tea.

Ginger has of course lots of other health benefits including reducing inflammation. We highly recommend having ginger everyday.

Reference:     "The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: A randomized, double-blind, placebo-controlled trial," Mozaffari-Khosravi H, Talaei B, et al, Complement Ther Med, 2014 Feb; 22(1): 9-16. (Address: Department of Nutrition, Faculty of Health, Yazd Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.).

(OMNS March 18, 2014) A middle-aged male had success rapidly reducing fast-acting alprazolam (Xanax) dosage by taking very high doses of niacin, along with gamma aminobutyric acid (GABA) and vitamin C. The individual had been on 1 mg/day Xanax for two years, a moderate dose but a long duration. As a result, he had been presenting increased anxiety, personality changes, and ringing in the ears (tinnitus), all side effects likely due to long-term alprazolam use. Typical withdrawal from this drug would involve substitution medication, about a 10% dose reduction per week, and take a matter of months.[1] A fast withdrawal is a 12.5 to 25% reduction per week.[2] On very high doses of niacin, vitamin C, and also GABA, this individual reported being able to cut the dose 60% down to 0.4 mg in one week. The dose was reduced by 90% (to 0.1 mg/day) in less than a month. He reported residual anxiety, but that it was substantially less than when fully medicated. After a total of five weeks, the medication intake was zero, with minimal residual anxiety.
Dosage

Niacin doses were between 6,000 and 12,000 mg/day. The individual reported reduced anxiety when taking the highest levels of niacin. Bowel-tolerance levels of vitamin C were taken daily, along with 750 mg of GABA twice daily. The individual also drank a quart of beet/cabbage soup broth daily for the first week, took 400 mg magnesium citrate/day, and took sublingual methylcobalamin (hi-absorption B-12), 5,000 mcg twice a week. During the initial total withdrawal from alprazolam, intake of GABA was 750 mg three times daily. The patient experienced side effects of daily but manageable anxiety. He also reported occasional nausea, possibly attributable to the GABA and almost certainly attributable to the extremely high niacin intake. He experienced increased frequency of urination, especially at night. Evening niacin doses as inositol hexaniacinate (a semi-sustained release, no-flush niacin) reduced nighttime urination. The individual used regular flush niacin about three-quarters of the time; inositol hexaniacinate constituted the balance. Dosage was divided into eight to ten 1,000 mg 8-10 such doses in 24 hours. Niacinamide was specifically not used, as its nausea threshold is low (under 6,000 mg day).
Niacin Mechanism of Action

Dr. Abram Hoffer had observed beneficial anticonvulsant activity by performing coadministration of niacinamide with anticonvulsants to treat epileptics in the early 1950s (personal communication). The dosage of the anticonvulsant could be reduced by 50% when 1,000-2,000 mg of niacin was administered with each meal. Hoffer noted that this was beneficial to patients because at the lower dose of anticonvulsant they were not nearly as drowsy.

In the late 1970s niacinamide was reported to be a ligand for the benzodiazepine receptor with physiological activities. Later studies suggested that the effect is not based on a direct specific interaction between niacinamide and benzodiazepine receptors.[3-5] However, ten years later a completely different benzodiazepine-binding receptor was identified in the peripheral nervous system.[6] This peripheral benzodiazepine receptor, known as translocator protein (TSPO), can modulate neurosteroids, which can alter neuronal excitability through interactions with GABA neurotransmitter ion channels. This can enhance GABA receptor function.[7]

A common question is, how exactly GABA taken orally can help if it does not readily cross the blood brain barrier (BBB). While GABA receptors are primarily known for their CNS locations and functions, there are also GABA receptors in the liver, immune cells, and lung cells that are accessible to bind GABA without crossing the BBB. The peripheral benzodiazepine receptor TSPO, as mentioned above, is one example. This can activate neurons in peripheral nerves that ultimately affect the CNS as well.

This case report described however, showed a positive result when using niacin. The common theme here is nicotinamide adenine dinucleotide (NAD) since both niacin and niacinamide are converted to NAD by the body. This indicates that therapeutic benefit is most likely being mediated via the increase in NAD levels, not through activation of the high affinity niacin G-protein coupled receptor, GPR109a, which niacinamide does not bind. NAD is used in over 450 reactions by the body, which is more than any other vitamin-derived molecule. The following are just a small list of the pathways that are dependent on it: drug/xenobiotic metabolism, steroid metabolism, basic glycolysis/TCA ATP generation, and many more.

These pathways are quite complicated, but one thing is for certain. We are susceptible to niacin deficiency as exemplified by the deadly pellagra epidemics in the first two decades of the 20 century, which killed over 100,000 people in the southern United States. Due to this epidemic, President Roosevelt commissioned epidemiologists to begin working on this serious problem. Many people with skin disorders were placed in sanitariums because common subclinical pellagra symptoms are dermatitis and sensitivity to sunlight.

Niacin is thought to help maintain homeostasis of neurotransmitters that are commonly unbalanced in the brains of those with anxiety [8], and it may also alter the metabolism of Xanax. As a primary participant in the hydroxylation reaction characteristic of phase 1 drug-metabolizing enzymes, NAD can speed up the metabolism of toxic waste products arising from the metabolism of the foreign alprazolam molecule.[8,9]

Specifically, Xanax is metabolized by the enzyme CYP3A4. Xanax induces CYP3A4 expression, meaning the body responds to Xanax administration by making more of the enzyme that degrades the Xanax molecule. The enzymatic reaction is dependent on the presence of the cofactor NAD, which is derived from niacin in the diet. The drug metabolizing enzyme reaction cannot proceed without the presence of all 3: the substrate (Xanax), the enzyme (CYP3A4), and the cofactor in NAD (derived from niacin). Individuals taking Xanax are likely to have high levels of the drug and the enzyme. But the metabolic reaction utilizing this enzyme that degrades the drug is commonly limited by insufficient levels of the cofactor, NAD.

By administering high doses of niacin, the concentration of NAD is increased, which then accelerates the rate of the drug-metabolizing reaction, ultimately clearing the drug from the body faster. The niacin flush / vasodilation is likely to aid in delivery to otherwise hard to reach anatomical locations as well as increase physical flow of the drug metabolites.
GABA

GABA seems likely to be a safer replacement to withdraw from as compared to simple weaning off of alprazolam. Using GABA is an orthomolecular approach, involving manipulating a substance normally present in the body. Ingested GABA will be metabolized by the normal endogenous mechanisms, for which humans have evolved to control properly. GABA will likely be cleared better than alprazolam and not be afflicted with the non-specific affects associated with the foreign molecule that GABA is.

GABA is one of the main inhibitory neurotransmitters in the brain. Oral GABA does not cross the blood brain barrier (BBB), but yet GABA oral ingestion still exerts the calming effect that is attributed to GABA activity. Low GABA is detectable in Xanax withdrawal, while plenty of GABA enables one to feel calm and to sleep better. GABA has been successfully used to assist with Xanax withdrawal .[10]

Another molecule, picamilon, is a niacin molecule bonded to GABA as one single molecule that may be useful. Picamilon crosses the BBB and then is broken down to niacin and GABA. Picamilon can help restore GABA receptor levels.

Also GABA is degraded into succinate, which in its own right can provide a significant source of energy as it directly enters the TCA cycle. Even though the exact reason is unknown, people taking GABA have noticed calming effects. The placebo effect may be responsible for part of the benefit. However, it is likely at high doses some GABA does get into the CNS.
Vitamin C

Because ascorbate in high doses is a strong antitoxin [11], it is considered to be an important inclusion. Flu-like symptoms common in benzodiazepine withdrawal may be ameliorated with vitamin C. Ascorbate also provides support for the liver, ranging from 500 mg/day preventing fatty buildup and cirrhosis to 5,000 mg of vitamin C per day appearing to actually flush fats from the liver, to 50,000 mg/day eliminating jaundice in under a week. [12]
Magnesium

Magnesium depletion is common in nearly all examples of people ingesting drugs. Thus, magnesium supplements are helpful. Nightly Epsom salt baths and 400 mg of magnesium citrate, once in the morning and once in the afternoon can facilitate a smooth transition away from alprazolam. Also realize that if you desire to measure your magnesium levels, be sure to do either the red blood cell test or the ionized magnesium test. However, do not test for serum magnesium levels. Serum magnesium concentrations are so tightly controlled that the results are invariably normal, so the test has been removed from the standard blood test suite.
Summary

Collectively this case history and biochemical rationale indicate that very high doses of niacin, GABA, and vitamin C together may greatly speed detox and reduce withdrawal symptoms from alprazolam. Additional therapeutic trials are warranted. It is emphasized that every person is different and that this experience may not be applicable to all. Alprazolam is a seriously addictive drug and withdrawal symptoms may be severe. Every individual should work closely with their healthcare provider.

(Dr. Todd Penberthy is a research consultant, medical writer and niacin researcher. A list of his recent papers is posted at http://www.cmescribe.com/resume/ Andrew W. Saul, OMNS Editor, is the general editor of the comprehensive textbook, The Orthomolecular Treatment of Chronic Disease, to be published in late June, 2014. http://www.doctoryourself.com/treatmentreviews.html )

References:

1. http://nationalpaincentre.mcmaster.ca/opioid/cgop_b_app_b06.html

2. http://pharmacy.oregonstate.edu/drug_policy/sites/default/files/ROAD/
Modules/Benzodiazepines/BenzodiazepinesSlideSet.pdf

3. Lapin IP. (1981) Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol-induced seizures. Pharmacology Biochemistry and Behavior, 14(5): 589-593.

4. Möhler H, Polc P, Cumin R, Pieri L, Kettler R. (1979) Nicotinamide is a brain constituent with benzodiazepine-like actions. Nature, 278(5704):563-5.

5. Tallman JF, Paul SM, Skolnick P, and Gallager DW. (1980) Receptors for the age of anxiety: pharmacology of the benzodiazepines. Science, 207(4428): 274-281.

6. Riond J, Mattei MG, Kaghad M, et al. (1991) Molecular cloning and chromosomal localization of a human peripheral-type benzodiazepine receptor. Eur J Biochem. 195(2):305-311.

7. Belelli D and Lambert JJ. (2005) Neurosteroids: endogenous regulators of the GABA(A) receptor. Nat Rev Neurosci, 6(7): 565-575.

8. Prousky JE. (2004) Niacinamide's Potent role in alleviating anxiety with its benzodiazepine-like properties: a case report. J Orthomol Med, 19(2): 104-110.

9. Prousky J and Seely D. (2005) The treatment of migraines and tension-type headaches with intravenous and oral niacin (nicotinic acid): systematic review of the literature. Nutr J, 4:3.

10. Bronson PJ. (2011) A Biochemists Experience with GABA. J Orthomolecular Med, 26:11-14.

11. Levy TE (2009) Curing the Incurable: Vitamin C, Infectious Diseases, and Toxins, 3rd Edition, Livon Books, ISBN: 978-0977952021

12. Cathcart, Robert F. III. (1981) The method of determining proper doses of vitamin C for the treatment of disease by titrating to bowel tolerance. Journal of Orthomolecular Psychiatry. 10:125-132.

Nutritional Medicine is Orthomolecular Medicine

Orthomolecular Medicine News Service, March 18, 2014
Supplements Accelerate Benzodiazepine Withdrawal
A Case Report and Biochemical Rationale
by W. Todd Penberthy, PhD and Andrew W. Saul
Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org

OMNS free subscription: http://orthomolecular.org/subscribe.html

OMNS archive link http://orthomolecular.org/resources/omns/index.shtml

Consuming fruits with white flesh like apples and pears can reduce the risk of stroke, new research published in Stroke: Journal of the American Heart Association has found.

A team of Dutch researchers followed 20,069 Dutch heart disease-free adults with an average age of 41 years for 10 years and found white flesh fruits – rich in the flavonoid quercetin – were better than green, orange/yellow and red/purple fruits for reducing the likelihood of stroke events.

"To prevent stroke, it may be useful to consume considerable amounts of white fruits and vegetables," said lead author Linda M Oude Griep, M.Sc, a postdoctoral fellow in human nutrition at Wageningen Uninversity. "For example, eating one apple a day is an easy way to increase white fruits and vegetable intake. However, other fruits and vegetable color groups may protect against other chronic diseases. Therefore, it remains of importance to consume a lot of fruits and vegetables."

A recent study [1] of the effect of B vitamins on a large group of participants reported an inverse relationship between blood serum levels of vitamin B6, methionine, and folate and the risk of lung cancer. High serum levels of vitamin B6, methionine and folate were associated with a 50% or greater reduction in lung cancer risk. This exciting finding has not been widely reported in the media, but it confirms a growing body of evidence gathered over the last 40 years that B vitamins are important for preventing diseases such as cancer.

The study gathered information about the lifestyle and diet of 385,000 people in several European countries. The average age was 64 years, and most had a history of drinking alcohol daily. Blood samples were then taken from these participants, and some of those (889) that developed lung cancer were analyzed for the level of several B vitamins and related biochemicals such as methionine, an essential amino acid. These nutrients were studied because they are known to be important in the metabolism of single carbon compounds, which is necessary for the synthesis and repair of DNA in the body's tissues [2]. Thus, B vitamins are helpful in preventing defects in DNA which can cause cancer [2-4].

Specifically, a high level of either vitamin B6, or methionine, or folate reduced the risk for lung cancer. High levels of all these nutrients together produced an even lower risk. The effects were large, so the results are highly significant.

The study divided the participants into three categories, depending on whether they currently smoked, had previously smoked, or had never smoked. While smoking is the most important lifestyle factor in the risk for lung cancer, interestingly, the effects of vitamin B6, methionine, and folate were fairly constant among the three categories. That is, those with higher levels of these B vitamins had a significantly lower risk of lung cancer no matter whether they smoked or not. The report emphasizes that this result strongly suggests that the effect of these essential nutrients in lowering the risk for cancer is real and not purely a statistical correlation. And, the report reiterates that smoking is dangerous, greatly increasing the risk for lung cancer in older people after decades of insult to the lungs.

Some widely-reported health studies have suggested that B vitamins can increase the risk of cancer. The theory is that these vitamins can help to prevent cancer from their effects in strengthening DNA synthesis and repair, but that when cancer is present, the vitamins supposedly help the cancer to grow [5]. However, there is a long history of health studies, including the above mentioned study, reporting that B vitamins including folate and vitamin B6 can help to prevent many types of cancer, such as breast, prostate and colorectal cancer [1-6].

It is just amazing how the news media could have missed this, but they pretty much did. In one much-publicized study [7] it was widely claimed that "Multivitamins increase deaths in older women!" Actually, the study found that B complex vitamins were associated with a 7 percent decrease in mortality, vitamin C was associated with a 4 percent decrease in mortality, vitamin D was associated with an 8 percent decrease in mortality, and several minerals were associated with a decrease in mortality.

Essential nutrients in a well-balanced diet, including B-complex, C, D, and E vitamins, are crucial to maintaining good health into old age for a variety of reasons. Persons taking adequate levels of vitamins will live longer, with fewer heart attacks [7] and other serious diseases such as diabetes [8], multiple sclerosis [9], and dementia [10].

 

The question begged by the report is, what role did vitamin supplements play in the blood levels reported for these essential nutrients? Taking a multivitamin that includes B-complex vitamins will obviously increase the blood levels of these essential nutrients. However, the value of supplements was not emphasized in the report.

 

So we will emphasize it here. Vitamins dramatically lower lung cancer risk. Supplements provide these nutrients in abundance. Modern diets do not.

References:

1. Johansson M, Relton C, Ueland PM, et al. Serum B vitamin levels and risk of lung cancer. JAMA. 2010 Jun 16;303(23):2377-85.

2. Xu X, Chen J. One-carbon metabolism and breast cancer: an epidemiological perspective. J Genet Genomics. 2009;36: 203-214.

3. Larsson SC, Orsini N, Wolk A. Vitamin B6 and risk of colorectal cancer: a meta-analysis of prospective studies. JAMA. 2010;303:1077-1083.

4. Ames BN. Prevention of mutation, cancer, and other age-associated diseases by optimizing micronutrient intake. J Nucleic Acids. 2010 Sep 22;2010. pii: 725071.

5. Mason JB. Unraveling the complex relationship between folate and cancer risk. Biofactors. 2011 Jul;37(4):253-60.

6. Giovannucci E. Epidemiologic studies of folate and colorectal neoplasia: a review. J Nutr. 2002;132(Suppl):S2350-S2355.

7. Mursu J, Robien K, Harnack LJ, Park K, Jacobs DR Jr. Dietary supplements and mortality rate in older women. The Iowa Women's Health Study. Arch Intern Med 2011. 171(18):1625-1633.

8. Pfister R, Sharp SJ, Luben R, et al. Plasma vitamin C predicts incident heart failure in men and women in European Prospective Investigation into Cancer and Nutrition-Norfolk prospective study. Am Heart J. 2011 Aug;162(2):246-53.

9. Harding AH, Wareham NJ, Bingham SA, et al. Plasma vitamin C level, fruit and vegetable consumption, and the risk of new-onset type 2 diabetes mellitus: the European prospective investigation of cancer--Norfolk prospective study. Arch Intern Med. 2008 Jul 28;168(14):1493-9.

10. Solomon AJ. Multiple sclerosis and vitamin D. Neurology. 2011 Oct 25;77(17):e99-e100.

11. Selhub J, Troen A, Rosenberg IH. B vitamins and the aging brain. Nutr Rev. 2010 Dec;68 Suppl 2:S112-8.

by Robert G. Smith, PhD

Nutritional Medicine is Orthomolecular Medicine

Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org

Recent research has revealed that vitamin K plays a vital role in maintaining healthy bones and arteries by keeping calcium in the bones and out of the arteries.

It matters greatly, however, which vitamin K you use as a supplement to prevent or treat osteoporosis.

The majority of vitamin K research to date has focused on vitamin K1, the dominant dietary form of vitamin K that occurs in green, leafy vegetables. Yet it appears that vitamin K2, which occurs in organ meats, egg yolks, and dairy products, is a more important inducer of bone mineralization in human osteoblasts (bone-building cells) than vitamin K1.

•    Vitamin K1 (5 mg) has been shown not to protect against age-related decline in bone mineral density.
•    Low dose vitamin K2 (45mg daily) has been shown to not only prevent bone loss but also to help maintain bone health in postmenopausal women.

The Japanese long ago recognized the power of vitamin K2 to maintain or restore bone health. In certain regions of Japan, a staple dish called natto or fermented soybean, frequently eaten several times a week, is uniquely rich in vitamin K2.

Two main forms of vitamin K

  • Vitamin K1 (phylloquinone or phytonadione) which is found in green leafy vegetables including lettuce, broccoli, and spinach and makes up about 90% of the vitamin K in a typical Australian diet.
  • Vitamin K2 (menaquinones) are also made by bacteria in the gut. Vitamin K2 does not strictly speaking qualify properly as a vitamin as it can be made from bacteria, however, it shows how incredibly important it is to have a healthy microbial system in our intestines.

Healthy gut

Conditions or drugs that impair fat absorption will also impair the absorption of Vitamin K, especially antibiotics. In their effort to rid foreign bacteria, antibiotics destroy the normal intestinal flora needed for Vitamin K synthesis, causing a deficiency of the vitamin.

Osteoarthritis, rheumatoid arthritis and heart disease

Vitamin K2 deficiency has also been found in the bones of patients with osteoarthritis, so it is likely that K2 supplementation may also help this condition.

For patients with established rheumatoid arthritis treated with alendronate, coadministration with vitamin K2 may provide further benefits.

Vitamin K2 also protects against heart disease.

Safety

Vitamin K2 is very safe, however, there has been a case published where a patient with a heart condition experienced mild low blood pressure when vitamin K2 was combined with his heart medication. Patients taking warfarin need to be carefully monitored if taking vitamin K2.
Vitamin K is required by the human liver to manufacture blood-clotting proteins. This is the basis for administering the vitamin K-blocking drug, warfarin to people who are at risk for blood clot formation.

Dosage

The lowest effective dosage of vitamin K is around 50 micrograms. Although dosages as high as 1000 microgram have been used. We recommend starting out with 100 microgram.

We also recommend combining vitamin K2 with vitamin D and a quality mineral supplement both to build strong bones and in the treatment of osteopenia or osteoporosis, as well as for supportive treatment of osteoarthritis and rheumatoid arthritis.

The research interest in this vitamin/hormone is intense and it has now become the most popular vitamin supplement. We think we good reason as so many of us avoid the sun completely.

The following article summarises some of the uses for vitamin D and the recommended dosages:

Orthomolecular Medicine News Service, January 17, 2013

Vitamin D is Now the Most Popular Vitamin by William B. Grant, Ph.D.

There were 3600 publications with vitamin D in the title or abstract in 2012 according to PubMed.gov. This brings the total number of publications on vitamin D listed at PubMed to 33,800 (http://www.ncbi.nlm.nih.gov/pubmed). This total compares to 35,100 on vitamin C or ascorbic acid, 21,700 on vitamin E, 19,100 on vitamin A, 17,600 on folate, and 12,000 on vitamin B12. However, since the beginning of 2000, there have been 20,500 publications on vitamin D but only 16,300 publications on vitamin C or ascorbic acid. Thus, vitamin D is the most popular vitamin even though strictly speaking it is not a vitamin. Instead, it is a necessary hormone that can be made in the body through the action of ultraviolet-B (UVB) light. However, it can also be obtained orally through the diet or supplements.

Top 16 Vitamin D Papers of 2012

The following list of top vitamin D papers for 2012 was selected from a search at PubMed.gov at the end of 2012. The list started out with 60 of candidate papers. This list was then sent to a panel of vitamin D researchers and advocates, who added a few more papers, then voted on the entire list. The final list has papers from a variety of health effects. Many other fine papers could not be included due to space limitations.

4,000 IU vitamin D3 was of great help during pregnancy

A topic that generated considerable interest this year was the role of vitamin D during pregnancy. In a pair of papers, researchers from the Medical University of South Carolina discussed the findings and implications of their randomized controlled trial of vitamin D supplementation during pregnancy [Hollis et al., 2012; Wagner et al., 2012]. Over 300 women were enrolled in the study. Women were assigned to take supplements containing 400, 2000, or 4000 IU/d vitamin D3 or a placebo. No adverse effects were found such as hypercalcemia or hypercalcuria. This study found that it took 4000 IU/d to raise serum 25-hydroxyvitamin D [25(OH)D] levels to about 40 ng/ml (To convert to nmol/l, multiple ng/ml by 2.5.), a nearly optimal level of 1,25-dihydroxyvitamin D. 1,25-dihydroxyvitamin D is the active or hormonal metabolite of vitamin D which among other things controls the expression of several hundred genes. (See Hossein-nezhad and Holick [2012] for a summary of the effects of vitamin D on fetal development.) In the study, those taking the higher vitamin D doses had significantly reduced risk of primary Cesarean section delivery and pre-eclampsia. Other adverse pregnancy outcomes occur with vitamin D deficiency such as premature delivery and low birth weight, but too few women were enrolled in this study to find statistically significant results on these conditions.

Mounting evidence that vitamin D deficiency is an important risk factor for autism

A study from Saudi Arabia examined the relation between serum 25(OH)D level and anti-myelin-associated glycoprotein (anti-MAG) auto-antibodies in autistic children near the age of eight years [Mostafa and Al-Ayadhi, 2012]. There was a very strong inverse relation between the two levels (r = -0.86, p

Low vitamin D during pregnancy is associated with childhood language impairment

A study in Perth, Australia measured serum 25(OH)D levels at 18 weeks into pregnancy, and then measured language impairment of the offspring at 5 and 10 years of age. It found that women with serum 25(OH)D levels below 18 ng/ml had children with twice the risk of clinically significant language difficulties compared to those with 25(OH)D levels above 28 ng/ml. Exactly why is not currently known, but there are many possibilities. It is noted that in the United States in the early 2000s, white women of childbearing age had mean 25(OH)D level of 26 ng/ml while black women of childbearing age had mean 25(OH)D level of 14 ng/ml. Both of these levels are low by current standards. As explained below, skin color is directly relevant to serum vitamin D levels produced by exposure to sunlight.

Higher vitamin D is associated with lower all-cause mortality rates

A topic of interest at the other end of life was the relation of mortality rate to serum 25(OH)D levels. A meta-analysis of 11 observational studies and 60,000 individuals found a reduction in risk over about 10 years for highest vs. lowest category of 25(OH)D level of mortality of 29% [Zittermann et al., 2012]. Comparing graded levels of intake, the reduction in risk was 14% for an increase of 5 ng/ml, 23% for an increase of 10 ng/ml, and 39% for an increase of 20 ng/ml in plasma levels of 25(OH)D, starting from a median of ~11 ng/ml. The participants starting with the lowest levels of serum 25(OH)D received the greatest benefits. Those who started with higher serum levels, closer to optimal (30-40 ng/ml), received less benefit from additional vitamin D. This relation between starting serum 25(OH)D levels and health outcome is not surprising because it is similar to many other health studies. Since 25(OH)D levels likely changed over the duration of the studies, and some participants died of unrelated causes, the actual effect of serum 25(OH)D level on mortality rate is greater than these estimates.

And less cardiovascular disease

Cardiovascular disease is an important contributor to mortality rates. A study of 11,000 patients in Kansas was reported. The patients had a mean age of 58±15 years, a body mass index of 30±8 kg/m2, and a mean serum 25(OH)D level of 24±14 ng/ml [Vacek et al., 2012]. Serum 25(OH)D levels below 30 ng/ml was significantly associated with several cardiovascular-related diseases, including hypertension, coronary artery disease, cardiomyopathy, and diabetes. After a period of 5.5 years, those with serum 25(OH)D levels below 30 ng/ml had twice the mortality rate of those with higher 25(OH)D levels.

And less risk of diabetes mellitus type 2

In a 2.7-year study of 2000 prediabetics, participants with the highest third of 25(OH)D levels (median, 30.1 ng/ml) had a reduction in risk of 28% for developing diabetes mellitus type 2 compared with participants in the lowest third (median, 12.8 ng/ml) [Pittas, 2012].

. . . and less diabetes mellitus type 1 (T1DM)

An observational study on insulin-dependent diabetes mellitus (T1DM) was based on 1000 U.S. military service personnel who developed this disease between 2002 and 2011 [Gorham et al., 2012]. They had provided blood samples between one and ten years prior to developing T1DM. They were carefully matched with another thousand service personnel who did not develop T1DM. There was a reduction in risk of 78% for developing T1DM for those with serum 25(OH)D levels above 24 ng/ml compared to those with levels above 24 ng/ml. This finding is highly statistically significant and is one of the strongest studies of its type.

Fewer bacterial and viral infections

The effect of vitamin D in reducing risk of infections is a topic of increasing interest. Vitamin D reduces risk of infections primarily by strengthening the innate immune system, primarily by inducing production of cathelicidin, a polypeptide with antimicrobial and antiendotoxin properties. It also shifts production of cytokines, a type of cell signaling molecule, away from proinflammatory ones, and has a number of other actions on both the innate and adaptive immune system [Lang et al., 2012]. While the effects of vitamin D have been found mostly for bacterial infections, some have also been reported for viral infections such as influenza, HIV, and hepatitis C [Lang et al., 2012]. In a supplementation study in Sweden involving 140 patients with frequent respiratory tract infections (RTIs) using 4000 IU/d vitamin D3, those in the supplementation group increased their serum 25(OH)D level to 53 ng/ml while those in the placebo group had levels near 27 ng/ml [Bergman et al., 2012]. Those taking vitamin D3 had a 23% reduction in RTIs and a 50% reduction in the number of days using antibiotics.

The benefits of vitamin D in reducing risk of cancer

One of the important and well-documented effects of vitamin D is reduced risk of cancer and increased survival after cancer diagnosis. There were 400 publications on vitamin D and cancer in 2012 according to PubMed.gov. Evidence from ecological, observational and laboratory studies have identified over 15 types of cancer for which higher solar UVB light and/or serum 25(OH)D levels are associated with reduced risk. Two of the papers are especially noteworthy. One, a study from Norway involving 658 patients with either breast, colon, lung, or lymphoma with serum 25(OH)D levels determined within 90 days of cancer diagnosis were followed for up to nine years [Tretli et al., 2012]. Compared to those with levels32 ng/ml had a reduction in risk for dying from cancer of 66%. To a cancer patient, this would be a lifeline.

Another cancer paper reported the results of supplementation with 4000 IU/d vitamin D3 of those with low-grade biopsy-assayed prostate cancer [Marshall et al., 2012]. Forty four patients successfully completed the one-year study. Twenty four of the subjects (55%) showed a decrease in the amount of cancer; five subjects (11%) showed no change; 15 subjects (34%) showed an increase. In comparison, with a historical group of 19 patients, only 4 (21%) had reductions in the amount of cancer, 3 (16%) showed no changes, and 12 (63%) showed an increase in cancer. Thus optimal vitamin D supplementation appears to be useful for treating those with cancer.

Falls and fractures

The classical role of vitamin D is to regulate calcium and phosphate absorption and metabolism, leading to strong bones. A pooled analysis of 31,000 persons (mean age, 76 years; 91% women) participating in randomized controlled trials of vitamin D supplementation who developed ~1000 incident hip fractures and ~3800 nonvertebral fractures found that those with the highest intake (median 800 IU/d; range 792-2000) had a 30% reduction in risk of hip fracture and a 14% reduced risk of nonvertebral fracture [Bischoff-Ferrari et al., 2012]. The role of vitamin D in neuromuscular control also plays an important role in reducing risk of falls and fractures.

Skin pigment adapts slowly to changed ultraviolet environment

Jablonski and Chaplin have published a series of papers on human skin pigmentation and its relation to solar ultraviolet radiation (UVR) [Jablonski and Chaplin, 2012]. Their primary thesis is that human skin pigmentation has adapted to UVR conditions where a group of people live for 50 generations, or about a thousand years. UVR from mid-day sunlight produces vitamin D, which provides important protection against many diseases, but sunlight also causes skin cancer and destruction of folate. Dark skin protects against free radical production, damage to DNA, cancer, and loss of folate. Thus, dark skin is best in the tropical planes regions while pale skin is best at high latitude regions. Those with skin adapted to UVB between 23° and 46° have the ability to tan, which is an adaptation to seasonal changes in solar UVB doses. However, in recent times, people have moved or traveled to regions where their skin pigmentation is not suited to the local UVR conditions. They discuss three examples: nutritional rickets, multiple sclerosis and melanoma. Their abstract concludes with this observation: "Low UVB levels and vitamin D deficiencies produced by changes in location and lifestyle pose some of the most serious disease risks of the twenty-first century."

Vitamin D levels for traditionally living Africans

A study on traditionally living Africans near the equator provides information on "normal" 25(OH)D levels. A paper was published on serum 25(OH)D levels of the Masai and the Hadzabe living near 4° S in Tanzania [Luxwolda et al., 2012]. They have skin type VI (very dark), wear a moderate amount of clothing, spend the major part of the day outdoors, but avoid direct exposure to sunlight when possible. The mean serum 25(OH)D levels of Maasai and Hadzabe were 48 (range 23-67) ng/ml and 44 (range 28-68) ng/ml, respectively. This finding suggests that serum 25(OH)D levels in the range of 40-50 ng/ml may be optimal for human health, which is generally consistent with observational studies for a number of health outcomes.
Vitamin D is made by exposure to sunlight to a significant degree only when the sun is 45 degrees or more above the horizon. At the latitudes of North America and Europe, this is summer midday sunlight between the hours of 11 a.m. and 3 p.m. In the early morning or late afternoon, light-skinned individuals may tan but they hardly get any vitamin D from sunlight. And in the winter, nobody gets much vitamin D from the sun. This explains the health benefits of taking supplements of vitamin D.

Summary and Conclusion

Thus, the evidence that serum 25(OH)D levels above 30-40 ng/ml are required for optimal health continues to mount. It takes 1000-4000 IU/d vitamin D3 to reach these levels in the absence of significant UVB exposure. The evidence comes from a variety of studies including observational and laboratory studies and randomized controlled trials (RCTs). While RCTs are required to demonstrate effectiveness and lack of harm for pharmaceutical drugs which, by definition, are artificial compounds, they should not be required for vitamin D since it is a natural compound important for all animal life including humans. In addition, RCTs on vitamin D are difficult to conduct due to other sources of vitamin D and reduced conversion of vitamin D to 25(OH)D level at higher serum levels.

It will take five years or more before large-scale RCTs testing vitamin D supplements are completed and reported. The adverse effects of oral intake of up to 4000 IU/d vitamin D3 and serum 25(OH)D levels up to 100 ng/ml are practically non-existent except for those individuals with conditions that may lead to hypercalcemia. However, some people have experienced hypertension, irritation and tachycardia at doses above 4000 IU/d. Thus, there seems to be little reason to wait for the RCTs before implementing vitamin D policies of higher oral intake and/or moderate UVB exposure and serum 25(OH)D levels.

Everyone in North America and Europe should take a supplement of 1000-4000 IU/d of vitamin D in the winter, and those with dark skin or office jobs should take vitamin D all year long. Supplementation with vitamin D is an inexpensive and very effective way to produce huge health benefits.

For further information on vitamin D, the interested reader is directed to these websites: http://www.Grassrootshealth.net, http://www.VitaminDCouncil.org, and http://www.VitaminDWiki.com.

Dr. Grant is director of http://www.sunarc.org .

Appreciation is expressed to all the scientists who have reviewed and contributed to this paper:
Barbara J. Boucher, M.D., Queen Mary University of London, Centre for Diabetes, Blizard Institute, London
John J. Cannell, M.D., Vitamin D Council, San Luis Obispo, CA
Brant Cebulla, Vitamin D Council, San Luis Obispo, CA
Cedric F. Garland, Dr. P.H., professor of Family and Preventive Medicine in the UCSD School of Medicine, and member of the Moores UC San Diego Cancer Center, LaJolla, CA
Afrozul Haq, Ph.D., Institutes of Pediatrics and Laboratory Medicine; Sheikh Khalifa Medical City; Abu Dhabi, United Arab Emirates
Robert P. Heaney, M.D., Osteoporosis Research Center, Creighton University Medical Center, Omaha, NE.
Perry Holman, Vitamin D Society, Canada
Johan E. Moan, M.D., Ph.D., Department of Radiation Biology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway
Stefan Pilz, M.D., Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Graz, Austria
Jörg Reichrath, M.D., Ph.D., Department of Dermatology; The Saarland University Hospital; Homburg/Saar, Germany.
And, the Editorial Review Board of the Orthomolecular Medicine News Service, listed further below.
 
References:
1. Bergman P, Norlin AC, Hansen S, Rekha RS, Agerberth B, Bj”rkhem-Bergman L, Ekstr”m L, Lindh JD, Andersson J. Vitamin D3 supplementation in patients with frequent respiratory tract infections: a randomised and double-blind intervention study. BMJ Open. 2012;2(6). pii: e001663.
2. Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, Flicker L, Wark J, Jackson RD, Cauley JA, Meyer HE, Pfeifer M, Sanders KM, St„helin HB, Theiler R, Dawson-Hughes B. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med. 2012;367(1):40-9.
3. Gorham ED, Garland CF, Burgi AA, Mohr SB, Zeng K, Hofflich H, Kim JJ, Ricordi C. Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case-control study. Diabetologia. 2012 Dec;55(12):3224-7.
4. Hollis BW, Wagner CL. Vitamin D and pregnancy: Skeletal effects, nonskeletal effects, and birth outcomes. Calcif Tissue Int. 2012 May 24. [Epub ahead of print]
5. Hossein-nezhad A, Holick MF. Optimize dietary intake of vitamin D: an epigenetic perspective. Curr Opin Clin Nutr Metab Care. 2012;15(6):567-79.
6. Jablonski NG, Chaplin G. Human skin pigmentation, migration and disease susceptibility. Philos Trans R Soc Lond B Biol Sci. 2012;367(1590):785-92.
7. Lang PO, Samaras N, Samaras D, Aspinall R. How important is vitamin D in preventing infections? Osteoporos Int. 2012 Nov 17. [Epub ahead of print]
8. Luxwolda MF, Kuipers RS, Kema IP, Janneke Dijck-Brouwer DA, Muskiet FA. Traditionally living populations in East Africa have a mean serum 25-hydroxyvitamin D concentration of 115 nmol/l. Br J Nutr. 2012;108(9):1557-61.
9. Marshall DT, Savage SJ, Garrett-Mayer E, Keane TE, Hollis BW, Host RL, Ambrose LH, Kindy MS, Gattoni-Celli S. Vitamin D3 supplementation at 4000 international units per day for one year results in a decrease of positive cores at repeat biopsy in subjects with low-risk prostate cancer under active surveillance. J Clin Endocrinol Metab. 2012;97(7):2315-24.
10. Mostafa GA, Al-Ayadhi LY. Reduced serum concentrations of 25-hydroxy vitamin D in children with autism: relation to autoimmunity. J Neuroinflammation. 2012;9:201.
11. Pittas AG, Nelson J, Mitri J, Hillmann W, Garganta C, Nathan DM, Hu FB, Dawson-Hughes B; Diabetes Prevention Program Research Group. Plasma 25-hydroxyvitamin D and progression to diabetes in patients at risk for diabetes: an ancillary analysis in the Diabetes Prevention Program. Diabetes Care. 2012;35(3):565-73.
12. Tretli S, Schwartz GG, Torjesen PA, Robsahm TE. Serum levels of 25-hydroxyvitamin D and survival in Norwegian patients with cancer of breast, colon, lung, and lymphoma: a population-based study. Cancer Causes Control. 2012;23(2):363-70.
13. Vacek JL, Vanga SR, Good M, Lai SM, Lakkireddy D, Howard PA. Vitamin D deficiency and supplementation and relation to cardiovascular health. Am J Cardiol. 2012;109(3):359-63.
14. Wagner CL, Taylor SN, Dawodu A, Johnson DD, Hollis BW. Vitamin D and its role during pregnancy in attaining optimal health of mother and fetus. Nutrients. 2012;4(3):208-30.
15. Whitehouse AJ, Holt BJ, Serralha M, Holt PG, Kusel MM, Hart PH. Maternal serum vitamin D levels during pregnancy and offspring neurocognitive development. Pediatrics. 2012;129(3):485-93.
16. Zittermann A, Iodice S, Pilz S, Grant WB, Bagnardi V, Gandini S. Vitamin D deficiency and mortality risk in the general population: A meta-analysis of prospective cohort studies. Am J Clin Nutr. 2012;95(1):91-100.
 
Nutritional Medicine is Orthomolecular Medicine
Orthomolecular medicine uses safe, effective nutritional therapy to fight illness. For more information: http://www.orthomolecular.org

Orthomolecular Medicine News Service, December 20, 2013

Vitamins Help Prevent Alzheimer's Disease

News Media Ignores Supplement Benefits . . . Again

(OMNS Dec 20, 2013) Nutritional supplementation with antioxidants and the B-complex vitamins has been shown to help prevent dementia. Half of all cases of Alzheimer's, the most common form of dementia, could be attributable to known dietary and lifestyle risk factors, and at least one fifth of current cases could be prevented right now.

But there's no money for prevention research, or sufficient political will to put prevention steps into action. To date, tens of billions of dollars have been spent on developing drugs, none of which have proven to stop or slow down the disease process. Yet already studies have shown that B vitamins have decreased the rate of brain shrinkage in the areas affected by Alzheimer's by almost nine times, as well as dramatically slowing down memory loss, in people with mild cognitive impairment, the precursor to Alzheimer's. Other promising preventive factors include exercise; controlling blood sugar and blood pressure; omega-3 fish oils; and getting involved in more social activities.

"Of the millions of pounds so far pledged for dementia research by the UK Government, none has been spent on prevention," says Professor David Smith from Oxford University. Dr. Smith's research group first identified that almost half of people over 60 have insufficient vitamin B12 to stop accelerated brain shrinkage. He believes we need to wake up to the fact that Alzheimer's is unlikely to be prevented by drugs.

Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment: http://www.pnas.org/content/early/2013/05/16/1301816110.full.pdf+html

Vitamins B12, B6 and folic acid shown to slow Alzheimer's in study: http://www.healthcentral.com/alzheimers/c/62/160989/vitamins-b12-shown-alzheimer/

Low vitamin B-12 status in confirmed Alzheimer's disease: http://jnnp.bmj.com/content/74/7/959.full.pdf+html

Ways to Use Nutrition and Lifestyle to Prevent Alzheimer's:

Eat fish - Eat fish three to four times a week, with at least two servings of oily fish (salmon, mackerel, herrings, kippers, sardines or tuna). Eat more nuts and seeds, preferably raw.

Up the antioxidants - Eat at least six servings of brightly colored vegetables and berries. Supplemental vitamin E (natural mixed tocopherols and tocotrienols) 400 IU and several thousand mg of vitamin C per day are both good ideas.

Cut sugar and refined carbs - Follow a low glycemic load, Mediterranean style diet, with slow-releasing "whole" carbohydrates. Minimize sugar, sugary drinks and juices.

Take B vitamins - Supplementing with vitamin B6 (20mg), B12 (500mcg), niacinamide (400 mg) and folic acid (400mcg) is a sensible precaution. People with raised homocysteine need higher supplemental vitamin intake to prevent brain shrinkage.

Limit coffee and stop smoking - Choose herbal or green tea instead.

Be active - Keep physically, socially and mentally active by learning new things.

Ray Hodgson tried this approach. He took B vitamins and has also improved his diet, eating more fish, vegetables, and whole foods, and cutting back on sugar. "The effect has been remarkable," he said. "Whereas I had been forgetting names and finding it hard to take on new skills, my memory and concentration are definitely better."

The world-wide costs of dementia in 2010 were estimated to be over $600 billion. Prevention of dementia would thus not only prevent a tremendous amount of human suffering but would also save huge sums of money.

To Learn More:

High doses of vitamins fight Alzheimer's disease: Why don't doctors recommend them now? http://orthomolecular.org/resources/omns/v04n25.shtml

Niacinamide restores cognition in Alzheimer's disease transgenic mice: http://www.jneurosci.org/content/28/45/11500.full.pdf+html (pdf download may take a few moments)

There is more on the internet about how niacinamide can help Alzheimer's, such as this article: http://www.alternative-medicine-digest.com/alzheimers-treatment.html

Vitamins E, C cut Alzheimer's risk, study says: http://www.cnn.com/2004/HEALTH/conditions/01/20/alzheimers.vitamins.reut/ http://www.theglobeandmail.com/life/vitamins-e-c-cut-alzheimers-risk-study-says/article992961/ People of retirement age who took supplements of both vitamin E and C daily saw their risk of Alzheimer's disease plummet by almost 80 per cent. Full text of original study: http://archneur.jamanetwork.com/article.aspx?articleid=785249

Grant WB. (2014) Trends in diet and Alzheimer's disease during the nutrition transition in Japan and developing countries. J Alzheimers Dis. 2014 Jan 1;38(3):611-20. doi: 10.3233/JAD-130719. http://www.ncbi.nlm.nih.gov/pubmed/24037034

Dean C. (2007) The Magnesium Miracle. Ballantine Press. ISBN-13: 9780345494580

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If you are a patient of the Hobart Naturopath, you can purchase your Bioceutical products directly from the Bioceuticals website.

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Coriolus PSP

trametes versicolor turkey tailCoriolus PSP is a special extract of the spores from the fungus Turkey tail. It’s botanical name is Trametes Versicolor (also known as Coriolus versicolor, or Kawaratake in Japanes, or Yun-Zhi in Chinese). The medicinal plant part is the fruiting body.

The active compounds are known as polysaccharide peptide (PSP) and polysaccharide krestin (PSK).

PSP and PSK have been investigated as adjuvant medicines during chemotherapy and radiation. Studies have found that these immune enhancing polysaccharides enhance quality of life of cancer patients.

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