Small bacterial overgrowth (SIBO) following food poisoning is a frequent cause of irritable bowel syndrome (IBS).
- The response of the body to an infection is to create an antibody to kill the bacteria or virus.
- Campylobacter jejune, shigella, salmonella, and E. Coli frequently cause SIBO and IBS with chronic diarrhoea.
- The immune system's response to infections by these organisms is to produce an antibody called cytolethal distending toxin B (CdtB).
- If the infection is resolved, the level of CdtB will eventually decrease to very low levels.
However, sometimes, the infection is not well resolved and another antibody is created (usually 10-12 weeks following the initial infection). This is the anti-vinculin antibody. Vinculin is a protein which acts as motor for joining one cell with another. Antibodies against vinculin cause autoimmune inflammation and further damage.
A new test measures the level and ratio of these two antibodies. It is a highly accurate and specific blood test for SIBO induced IBS. The sample is analyses in the US. The test is provided by Nutrisearch.